Technical Data Sheet

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Frontier, research, acids, boronic, 1,4-addition, coupling, Chem., cross-coupling, with, Rev.,, known, toxicity,, Organometallic, 2003,, 103,, other, products, product, responsible, 2002,, Asymmetric, organic, applications, Recent, development, (Ed.)., Bond, Scientific, Reactions.,


Frontier Scientific
For Research Only(435) 753-1901
World Headquarters
PO Box 31
Logan, UT 84323
Technical Data Sheet
Not intended or approved for
diagnostic or therapeutic use
Catalog #
Not specified
3-(Aminomethyl)phenylboronic acid hydrochlorideName
Frontier Scientific, Inc. warrants the product conforms to the specifications stated herein. In the event of nonconformity, Frontier will replace
products or refund purchase price, at its sole option, and Frontier shall not be responsible for any other loss or damage, whether known or
foreseeable to Frontier. No other warranties apply, express or implied, including but not limited to warranty of fitness for any purpose or implied
warranty of merchantability. Purchaser is solely responsible for all consequences of its use of the product and Frontier assumes no responsibility
therefore, including success of purchaser's research and development, or health or safety of any uses of the product.
The toxicological and pharmacological properties of this compound are not fully known. For further information see the
MSDS on request. This item is manufactured, shipped according to standard practices, and intended for research and
development in a laboratory utilizing prudent procedures for handling chemicals of unknown toxicity, under the supervision of
persons technically qualified to evaluate potential risks and authorized to enforce appropriate health and safety measures.
As with all research chemicals, precautions should be taken to avoid unnecessary exposures or risks.
Boronic acids are often used in metal-catalyzed cross-coupling for C-C, C-N bond formation, and C-H functionalization.(1-7)
The air, moisture, and thermal stability of boronic acids, as well as functional group tolerance, low toxicity, and commercial
availability have made boronic acids ideally suited for coupling purposes.(1-7) The widely utilized Suzuki-Miyaura coupling
allows for the coupling of boronic acids with carbon halides and surrogates.(1,2,5-7) Other known chemistry may includes
1,4-addition to activated alkenes(3), 1,2-addition to carbonyls and imines(3), addition to anhydrides(3), 1,4-addition to
a,ß-unsaturated ketones(4), and 1,4-addition to esters and amides(4).
(1) Hall, G. H.; (Ed.). (2011) Boronic Acids (Vols. 1-2). Weinheim, Germany: Wiley-VCH Verlag & Co.
(2) Molander, G. A.; (Ed.). (2008) Handbook of Reagents for Organic Synthesis: Catalyst Components for Coupling
Reactions. West Sussex, England: John Wiley & Sons.
(3) Fagnou, K.; Lautens, M.; Rhodium-Catalyzed Carbon-Carbon Bond Forming Reactions of Organometallic
Compounds. Chem. Rev., 2003, 103, 169-196.
(4) Hayashi, T.; Yamasaki, K.; Rhodium Catalyzed Asymmetric 1,4-Addition and Its Related Asymmetric
Reactions. Chem. Rev., 2003, 103, 2829-2844.
(5) Kotha, S.; Lahiri, K.; Kashinath, D.; Recent applications of the Suzuki-miyaura cross-coupling reaction in
organic synthesis. Tetrahedron, 2002, 58, 9633-9695.
(6) Hassan, J.; Sevignon, M.; Gozzi, C.; Shulz, E.; Lemaire, M.; Aryl-Aryl Bond Formation One Century after the
Discovery of the Ullmann Reaction. Chem. Rev., 2002, 102, 1359-1469.
(7) Suzuki, A.; Recent advances in the cross-coupling reactions of organoboron derivatives with organic
elcetrophiles, 1995-1998. Journal of Organometallic Chemistry, 1999, 576, 147-168.
A1333 Revision: 1
Frontier Scientific products are sold for research and development purposes only and are not for diagnostic or therapeutic use. Materials in the publication, as well as
applications and methods and use may be covered by one or more U.S or foreign patents or patents pending. We welcome inquiries about licensing the use of our
trademarks and technologies at

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